Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp72 | Thyroid Autoimmune Disorders | ECE2019

Microarray profile of CD19+B cells from Graves’ disease patients reveals potential molecular mechanisms associated with the proliferation of B cell signaling

Jiang Xuechao , Wang Yonghui , Yang Qian , He Leqi , Li Xiaoying , Wang Wei , Liu Jun , Zha Bingbing

Background: GravesÂ’ disease (GD) is a common autoimmune disorder characterized by the production of autoantibodies targeting the thyroid, leading to hypothyroidism. It is widely accepted that B lymphocytes play a significant role in GD as they are the source of autoantibodies (TRAb) against the thyroid-stimulating hormone receptor (TSHR). Previously, we reported that B cells infiltrate the thyroid tissue of GD patients, and in this study we observed that the percentage of...